Ontology highlight
ABSTRACT:
SUBMITTER: Burkhardt DH
PROVIDER: S-EPMC5318159 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Burkhardt David H DH Rouskin Silvi S Zhang Yan Y Li Gene-Wei GW Weissman Jonathan S JS Gross Carol A CA
eLife 20170131
Bacterial mRNAs are organized into operons consisting of discrete open reading frames (ORFs) in a single polycistronic mRNA. Individual ORFs on the mRNA are differentially translated, with rates varying as much as 100-fold. The signals controlling differential translation are poorly understood. Our genome-wide mRNA secondary structure analysis indicated that operonic mRNAs are comprised of ORF-wide units of secondary structure that vary across ORF boundaries such that adjacent ORFs on the same m ...[more]