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C21orf57 is a human homologue of bacterial YbeY proteins.

ABSTRACT: The product of the human C21orf57 (huYBEY) gene is predicted to be a homologue of the highly conserved YbeY proteins found in nearly all bacteria. We show that, like its bacterial and chloroplast counterparts, the HuYbeY protein is an RNase and that it retains sufficient function in common with bacterial YbeY proteins to partially suppress numerous aspects of the complex phenotype of an Escherichia coli ?ybeY mutant. Expression of HuYbeY in Saccharomyces cerevisiae, which lacks a YbeY homologue, results in a severe growth phenotype. This observation suggests that the function of HuYbeY in human cells is likely regulated through specific interactions with partner proteins similarly to the way YbeY is regulated in bacteria.

SUBMITTER: Ghosal A

PROVIDER: S-EPMC5318257 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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C21orf57 is a human homologue of bacterial YbeY proteins.

Ghosal Anubrata A Köhrer Caroline C Babu Vignesh M P VMP Yamanaka Kinrin K Davies Bryan W BW Jacob Asha I AI Ferullo Daniel J DJ Gruber Charley C CC Vercruysse Maarten M Walker Graham C GC

Biochemical and biophysical research communications 20170130 3

The product of the human C21orf57 (huYBEY) gene is predicted to be a homologue of the highly conserved YbeY proteins found in nearly all bacteria. We show that, like its bacterial and chloroplast counterparts, the HuYbeY protein is an RNase and that it retains sufficient function in common with bacterial YbeY proteins to partially suppress numerous aspects of the complex phenotype of an Escherichia coli ΔybeY mutant. Expression of HuYbeY in Saccharomyces cerevisiae, which lacks a YbeY homologue, ...[more]

PMID: 28153719

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