Ontology highlight
ABSTRACT:
SUBMITTER: Thanabalasuriar A
PROVIDER: S-EPMC5318399 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Thanabalasuriar Ajitha A Neupane Arpan S AS Wang Jing J Krummel Matthew F MF Kubes Paul P
Cell reports 20160901 12
iNKT cells are a subset of innate T cells that recognize glycolipids presented on CD1d molecules and protect against bacterial infections, including S. pneumoniae. Using lung intravital imaging, we examined the behavior and mechanism of pulmonary iNKT cell activation in response to the specific iNKT cell ligand α-galactosylceramide or S. pneumoniae infection. In untreated mice, the major fraction of iNKT cells resided in the vasculature, but a small critical population resided in the extravascul ...[more]