Ontology highlight
ABSTRACT:
SUBMITTER: Kilpatrick BS
PROVIDER: S-EPMC5318655 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Kilpatrick Bethan S BS Eden Emily R ER Hockey Leanne N LN Yates Elizabeth E Futter Clare E CE Patel Sandip S
Cell reports 20170201 7
Membrane contact sites are regions of close apposition between organelles that facilitate information transfer. Here, we reveal an essential role for Ca<sup>2+</sup> derived from the endo-lysosomal system in maintaining contact between endosomes and the endoplasmic reticulum (ER). Antagonizing action of the Ca<sup>2+</sup>-mobilizing messenger NAADP, inhibiting its target endo-lysosomal ion channel, TPC1, and buffering local Ca<sup>2+</sup> fluxes all clustered and enlarged late endosomes/lysoso ...[more]