FAK-inhibition opens the door to checkpoint immunotherapy in Pancreatic Cancer.
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ABSTRACT:
SUBMITTER: Symeonides SN
PROVIDER: S-EPMC5319091 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
FAK-inhibition opens the door to checkpoint immunotherapy in Pancreatic Cancer.
Symeonides Stefan N SN Anderton Stephen M SM Serrels Alan A
Journal for immunotherapy of cancer 20170221
Immunotherapy has had remarkable success in the treatment of some cancer types. However, pancreatic cancer has remained largely refractory to immunotherapy, including immune checkpoint inhibitors. Recently, Jiang and colleagues identified a key role for FAK in regulating the composition of the fibrotic and immuno-suppressive pancreatic tumour niche, and showed that FAK inhibitors can be used in combination with immune checkpoint blockade and gemcitabine chemotherapy to significantly delay pancre ...[more]
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