Ontology highlight
ABSTRACT:
SUBMITTER: Choi SY
PROVIDER: S-EPMC5319158 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Choi Seon Young SY Kim Hang-Rae HR Ryu Pan Dong PD Lee So Yeong SY
BMC pharmacology & toxicology 20170221 1
<h4>Background</h4>Side-population (SP) cells that exclude anti-cancer drugs have been found in various tumor cell lines. Moreover, SP cells have a higher proliferative potential and drug resistance than main population cells (Non-SP cells). Also, several ion channels are responsible for the drug resistance and proliferation of SP cells in cancer.<h4>Methods</h4>To confirm the expression and function of voltage-gated potassium (Kv) channels of SP cells, these cells, as well as highly expressed A ...[more]