TSER polymorphism is not associated with risk of pediatric acute lymphoblastic leukemia: A meta-analysis.

ABSTRACT:

Background

Accumulating studies have explored the effect of thymidylate synthase enhancer region (TSER) variation on risk of pediatric acute lymphoblastic leukemia (ALL) with controversial results. Therefore, this quantitative meta-analysis was performed to assess synthetically the association of TSER variation with susceptibility to develop pediatric ALL.

Methods

The PubMed, ScienceDirect, Google Scholar, Wanfang Database, and China National Knowledge Infrastructure were systematically retrieved to obtain the published case-control studies about the relationship between TSER variation and pediatric ALL risk. The quality assessment of the included studies was preformed and relevant information was collected. Odds ratios (ORs) and 95% confidence intervals (CIs) were applied t

SUBMITTER: Qiao Z 

PROVIDER: S-EPMC5319533 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature