Ontology highlight
ABSTRACT:
SUBMITTER: Min H
PROVIDER: S-EPMC5319662 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
BMB reports 20170101 1
High-dose caffeine uptake is a developmental stressor and causes food-avoidance behavior (aversion phenotype) in C. elegans, but its mode of action is largely unknown. In this study, we investigated the molecular basis of the caffeineinduced aversion behavior in C. elegans. We found that aversion phenotype induced by 30 mM caffeine was mediated by JNK/MAPK pathway, serotonergic and dopaminergic neuroendocrine signals. In this process, the dopaminergic signaling appears to be the major pathway be ...[more]