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ABSTRACT: Introduction
White matter hyperintensities (WMHs) increase the risk of Alzheimer's disease (AD). Whether WMHs are associated with the decline of functional neural networks in AD is debated.Method
Resting-state functional magnetic resonance imaging and WMH were assessed in 78 subjects with increased amyloid levels on AV-45 positron emission tomography (PET) in different clinical stages of AD. We tested the association between WMH volume in major atlas-based fiber tract regions of interest (ROIs) and changes in functional connectivity (FC) between the tracts' projection areas within the default mode network (DMN).Results
WMH volume within the inferior fronto-occipital fasciculus (IFOF) was the highest among all tract ROIs and associated with reduced FC in IFOF-connected DMN areas, independently of global AV-45 PET. Higher AV-45 PET contributed to reduced FC in IFOF-connected, temporal, and parietal DMN areas.Conclusions
High fiber tract WMH burden is associated with reduced FC in connected areas, thus adding to the effects of amyloid pathology on neuronal network function.
SUBMITTER: Taylor ANW
PROVIDER: S-EPMC5319922 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Taylor Alexander N W ANW Kambeitz-Ilankovic Lana L Gesierich Benno B Simon-Vermot Lee L Franzmeier Nicolai N Araque Caballero Miguel Á MÁ Müller Sophia S Hesheng Liu L Ertl-Wagner Birgit B Bürger Katharina K Weiner Michael W MW Dichgans Martin M Duering Marco M Ewers Michael M
Alzheimer's & dementia : the journal of the Alzheimer's Association 20160716 3
<h4>Introduction</h4>White matter hyperintensities (WMHs) increase the risk of Alzheimer's disease (AD). Whether WMHs are associated with the decline of functional neural networks in AD is debated.<h4>Method</h4>Resting-state functional magnetic resonance imaging and WMH were assessed in 78 subjects with increased amyloid levels on AV-45 positron emission tomography (PET) in different clinical stages of AD. We tested the association between WMH volume in major atlas-based fiber tract regions of ...[more]