Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC5320058 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Zhao Y Y Carroll D W DW You Y Y Chaiswing L L Wen R R Batinic-Haberle I I Bondada S S Liang Y Y St Clair D K DK
Redox biology 20170210
The signaling of reactive oxygen species (ROS) is essential for the maintenance of normal cellular function. However, whether and how ROS regulate stem cells are unclear. Here, we demonstrate that, in transgenic mice expressing the human manganese superoxide dismutase (MnSOD) gene, a scavenger of ROS in mitochondria, the number and function of mouse hematopoietic stem/progenitor cells (HSPC) under physiological conditions are enhanced. Importantly, giving MnTnBuOE-2-PyP<sup>5+</sup>(MnP), a redo ...[more]