Ontology highlight
ABSTRACT:
SUBMITTER: Shin HW
PROVIDER: S-EPMC532010 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Shin Hye-Won HW Morinaga Naoko N Noda Masatoshi M Nakayama Kazuhisa K
Molecular biology of the cell 20040922 12
Small GTPases of the ADP-ribosylation factor (ARF) family play a key role in membrane trafficking by regulating coated vesicle formation, and guanine nucleotide exchange is essential for the ARF function. Brefeldin A blocks the ARF-triggered coat assembly by inhibiting the guanine nucleotide exchange on ARFs and causes disintegration of the Golgi complex and tubulation of endosomal membranes. BIG2 is one of brefeldin A-inhibited guanine nucleotide exchange factors for the ARF GTPases and is asso ...[more]