Ontology highlight
ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC532025 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Lee Susan S Rivero Francisco F Park Kyung Chan KC Huang Emerald E Funamoto Satoru S Firtel Richard A RA
Molecular biology of the cell 20041013 12
We have identified a new Dictyostelium p21-activated protein kinase, PAKc, that we demonstrate to be required for proper chemotaxis. PAKc contains a Rac-GTPase binding (CRIB) and autoinhibitory domain, a PAK-related kinase domain, an N-terminal phosphatidylinositol binding domain, and a C-terminal extension related to the Gbetagamma binding domain of Saccharomyces cerevisiae Ste20, the latter two domains being required for PAKc transient localization to the plasma membrane. In response to chemoa ...[more]