Ontology highlight
ABSTRACT:
SUBMITTER: Nagahama M
PROVIDER: S-EPMC532049 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Nagahama Masami M Hara Yoshimitsu Y Seki Akihiro A Yamazoe Takeshi T Kawate Yumiko Y Shinohara Takashi T Hatsuzawa Kiyotaka K Tani Katsuko K Tagaya Mitsuo M
Molecular biology of the cell 20041006 12
NVL (nuclear VCP-like protein), a member of the AAA-ATPase family, is known to exist in two forms with N-terminal extensions of different lengths in mammalian cells. Here, we show that they are localized differently in the nucleus; NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Mutational analysis demonstrated the presence of two nuclear localization signals in NVL2, one of which is shared with NVL1. In addition, a nucleolar localization signal was fo ...[more]