Ontology highlight
ABSTRACT:
SUBMITTER: Oliver D
PROVIDER: S-EPMC5320502 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Oliver David D Ji Hao H Liu Piaomu P Gasparian Alexander A Gardiner Ellen E Lee Samuel S Zenteno Adrian A Perinskaya Lillian O LO Chen Mengqian M Buckhaults Phillip P Broude Eugenia E Wyatt Michael D MD Valafar Homayoun H Peña Edsel E Shtutman Michael M
Scientific reports 20170222
Targeted cancer therapeutics aim to exploit tumor-specific, genetic vulnerabilities specifically affecting neoplastic cells without similarly affecting normal cells. Here we performed sequencing-based screening of an shRNA library on a panel of cancer cells of different origins as well as normal cells. The shRNA library was designed to target a subset of genes previously identified using a whole genome screening approach. This focused shRNA library was infected into cells followed by analysis of ...[more]