Declaring a tuberculosis outbreak over with genomic epidemiology.
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ABSTRACT:
SUBMITTER: Hatherell HA
PROVIDER: S-EPMC5320671 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Declaring a tuberculosis outbreak over with genomic epidemiology.
Hatherell Hollie-Ann HA Didelot Xavier X Pollock Sue L SL Tang Patrick P Crisan Anamaria A Johnston James C JC Colijn Caroline C Gardy Jennifer L JL
Microbial genomics 20160531 5
We report an updated method for inferring the time at which an infectious disease was transmitted between persons from a time-labelled pathogen genome phylogeny. We applied the method to 48 <i>Mycobacterium tuberculosis</i> genomes as part of a real-time public health outbreak investigation, demonstrating that although active tuberculosis (TB) cases were diagnosed through 2013, no transmission events took place beyond mid-2012. Subsequent cases were the result of progression from latent TB infec ...[more]
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