Ontology highlight
ABSTRACT:
SUBMITTER: Comaills V
PROVIDER: S-EPMC5320932 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Comaills Valentine V Kabeche Lilian L Morris Robert R Buisson Rémi R Yu Min M Madden Marissa Wells MW LiCausi Joseph A JA Boukhali Myriam M Tajima Ken K Pan Shiwei S Aceto Nicola N Sil Srinjoy S Zheng Yu Y Sundaresan Tilak T Yae Toshifumi T Jordan Nicole Vincent NV Miyamoto David T DT Ting David T DT Ramaswamy Sridhar S Haas Wilhelm W Zou Lee L Haber Daniel A DA Maheswaran Shyamala S
Cell reports 20161201 10
TGF-β secreted by tumor stroma induces epithelial-to-mesenchymal transition (EMT) in cancer cells, a reversible phenotype linked to cancer progression and drug resistance. However, exposure to stromal signals may also lead to heritable changes in cancer cells, which are poorly understood. We show that epithelial cells failing to undergo proliferation arrest during TGF-β-induced EMT sustain mitotic abnormalities due to failed cytokinesis, resulting in aneuploidy. This genomic instability is assoc ...[more]