IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice.
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ABSTRACT:
SUBMITTER: Choi JH
PROVIDER: S-EPMC5321007 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice.
Choi Jin Huk JH Wang Kuan-Wen KW Zhang Duanwu D Zhan Xiaowei X Wang Tao T Bu Chun-Hui CH Behrendt Cassie L CL Zeng Ming M Wang Ying Y Misawa Takuma T Li Xiaohong X Tang Miao M Zhan Xiaoming X Scott Lindsay L Hildebrand Sara S Murray Anne R AR Moresco Eva Marie Y EM Hooper Lora V LV Beutler Bruce B
Proceedings of the National Academy of Sciences of the United States of America 20170130 7
Class-switch recombination (CSR) alters the Ig isotype to diversify antibody effector functions. IgD CSR is a rare event, and its regulation is poorly understood. We report that deficiency of 53BP1, a DNA damage-response protein, caused age-dependent overproduction of secreted IgD resulting from increased IgD CSR exclusively within B cells of mucosa-associated lymphoid tissues. IgD overproduction was dependent on activation-induced cytidine deaminase, hematopoietic MyD88 expression, and an intac ...[more]
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