Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC5321016 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Zhang Zhuan Z Gong Yu-Kang YK Zhou Qiang Q Hu Yu Y Ma Hong-Min HM Chen Yong-Sheng YS Igarashi Yasuhiro Y Pan Lifeng L Tang Gong-Li GL
Proceedings of the National Academy of Sciences of the United States of America 20170130 7
Ranking among the most effective anticancer drugs, anthracyclines represent an important family of aromatic polyketides generated by type II polyketide synthases (PKSs). After formation of polyketide cores, the post-PKS tailoring modifications endow the scaffold with various structural diversities and biological activities. Here we demonstrate an unprecedented four-enzyme-participated hydroxyl regioisomerization process involved in the biosynthesis of kosinostatin. First, KstA15 and KstA16 funct ...[more]