Ontology highlight
ABSTRACT:
SUBMITTER: Gray HB
PROVIDER: S-EPMC5321091 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Israel journal of chemistry 20160729 9-10
Prior to 1950, the consensus was that biological transformations occurred in two-electron steps, thereby avoiding the generation of free radicals. Dramatic advances in spectroscopy, biochemistry, and molecular biology have led to the realization that protein-based radicals participate in a vast array of vital biological mechanisms. Redox processes involving high-potential intermediates formed in reactions with O<sub>2</sub> are particularly susceptible to radical formation. Clusters of tyrosine ...[more]