Increasing insulin resistance accentuates the effect of triglyceride-associated loci on serum triglycerides during 5 years.

ABSTRACT: Blood concentrations of triglycerides are influenced by genetic factors as well as a number of environmental factors, including adiposity and glucose homeostasis. The aim was to investigate the association between a serum triglyceride weighted genetic risk score (wGRS) and changes in fasting serum triglyceride level over 5 years and to test whether the effect of the wGRS was modified by 5 year changes of adiposity, insulin resistance, and lifestyle factors. A total of 3,474 nondiabetic individuals from the Danish Inter99 cohort participated in both the baseline and 5 year follow-up physical examinations and had information on the wGRS comprising 39 genetic variants. In a linear regression model adjusted for age, sex, and baseline serum triglyceride, the wGRS was associated with increased s

SUBMITTER: Justesen JM 

PROVIDER: S-EPMC5321221 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature