Ontology highlight
ABSTRACT:
SUBMITTER: Loos JA
PROVIDER: S-EPMC5321462 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Loos Julia A JA Dávila Valeria A VA Rodrígues Christian R CR Petrigh Romina R Zoppi Jorge A JA Crocenzi Fernando A FA Cumino Andrea C AC
PLoS neglected tropical diseases 20170209 2
Metformin (Met) is an anti-hyperglycemic and potential anti-cancer agent which may exert its anti-proliferative effects via the induction of energetic stress. In this study we investigated the in vitro and in vivo efficacy of Met against the larval stage of Echinococcus granulosus. Metformin showed significant dose- and time-dependent killing effects on in vitro cultured protoscoleces and metacestodes. Notably, the combination of Met together with the minimum effective concentration of ABZSO had ...[more]