Ontology highlight
ABSTRACT:
SUBMITTER: Ballandras-Colas A
PROVIDER: S-EPMC5321526 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Ballandras-Colas Allison A Maskell Daniel P DP Serrao Erik E Locke Julia J Swuec Paolo P Jónsson Stefán R SR Kotecha Abhay A Cook Nicola J NJ Pye Valerie E VE Taylor Ian A IA Andrésdóttir Valgerdur V Engelman Alan N AN Costa Alessandro A Cherepanov Peter P
Science (New York, N.Y.) 20170101 6320
Retroviral integrase (IN) functions within the intasome nucleoprotein complex to catalyze insertion of viral DNA into cellular chromatin. Using cryo-electron microscopy, we now visualize the functional maedi-visna lentivirus intasome at 4.9 angstrom resolution. The intasome comprises a homo-hexadecamer of IN with a tetramer-of-tetramers architecture featuring eight structurally distinct types of IN protomers supporting two catalytically competent subunits. The conserved intasomal core, previousl ...[more]