Prognostic significance of day 14 bone marrow evaluation in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia.
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ABSTRACT:
SUBMITTER: Short NJ
PROVIDER: S-EPMC5321530 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
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Prognostic significance of day 14 bone marrow evaluation in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia.
Short Nicholas J NJ Kantarjian Hagop M HM Sasaki Koji K Cortes Jorge E JE Ravandi Farhad F Thomas Deborah A DA Garcia-Manero Guillermo G Khouri Issa I Kebriaei Partow P Champlin Richard E RE Pierce Sherry S Issa Ghayas C GC Konopleva Marina M Kadia Tapan M TM Bueso-Ramos Carlos C Khoury Joseph D JD Jain Nitin N O'Brien Susan M SM Jabbour Elias E
Cancer 20160810 24
<h4>Background</h4>The role of day 14 (D14) bone marrow (BM) assessment in detecting increased blasts in patients undergoing induction for acute lymphoblastic leukemia (ALL) is not well defined.<h4>Methods</h4>This study evaluated 389 adolescent and adult patients with previously untreated Philadelphia chromosome-negative ALL who received frontline induction chemotherapy and for whom a D14 BM assessment was performed.<h4>Results</h4>A D14 BM blast proportion < 10% (including blast-free aplastic ...[more]
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