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Prognostic significance of day 14 bone marrow evaluation in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia.

ABSTRACT: The role of day 14 (D14) bone marrow (BM) assessment in detecting increased blasts in patients undergoing induction for acute lymphoblastic leukemia (ALL) is not well defined.This study evaluated 389 adolescent and adult patients with previously untreated Philadelphia chromosome-negative ALL who received frontline induction chemotherapy and for whom a D14 BM assessment was performed.A D14 BM blast proportion?

SUBMITTER: Short NJ 

PROVIDER: S-EPMC5321530 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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<h4>Background</h4>The role of day 14 (D14) bone marrow (BM) assessment in detecting increased blasts in patients undergoing induction for acute lymphoblastic leukemia (ALL) is not well defined.<h4>Methods</h4>This study evaluated 389 adolescent and adult patients with previously untreated Philadelphia chromosome-negative ALL who received frontline induction chemotherapy and for whom a D14 BM assessment was performed.<h4>Results</h4>A D14 BM blast proportion < 10% (including blast-free aplastic  ...[more]

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