Ontology highlight
ABSTRACT:
SUBMITTER: Cho CF
PROVIDER: S-EPMC5321554 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Cho Choi-Fong CF Lee Kyungheon K Speranza Maria-Carmela MC Bononi Fernanda C FC Viapiano Mariano S MS Luyt Leonard G LG Weissleder Ralph R Chiocca E Antonio EA Lee Hakho H Lawler Sean E SE
ACS combinatorial science 20160523 6
Molecular targeting using ligands specific to disease markers has shown great promise for early detection and directed therapy. Bead-based combinatorial libraries have served as powerful tools for the discovery of novel targeting agents. Screening platforms employing magnetic capture have been used to achieve rapid and efficient identification of high-affinity ligands from one-bead-one-compound (OBOC) libraries. Traditional manual methodologies to isolate magnetized "hit" beads are tedious and l ...[more]