Ontology highlight
ABSTRACT: Conclusion
Lymphocyte migration is facilitated by the unique structure of HSECs. Intracellular crawling may contribute to optimal lymphocyte positioning in liver tissue during chronic hepatitis. (Hepatology 2017;65:294-309).
SUBMITTER: Patten DA
PROVIDER: S-EPMC5321563 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Patten Daniel A DA Wilson Garrick K GK Bailey Dalan D Shaw Robert K RK Jalkanen Sirpa S Salmi Marko M Rot Antal A Weston Chris J CJ Adams David H DH Shetty Shishir S
Hepatology (Baltimore, Md.) 20161125 1
The recruitment of lymphocytes via the hepatic sinusoidal channels and positioning within liver tissue is a critical event in the development and persistence of chronic inflammatory liver diseases. The hepatic sinusoid is a unique vascular bed lined by hepatic sinusoidal endothelial cells (HSECs), a functionally and phenotypically distinct subpopulation of endothelial cells. Using flow-based adhesion assays to study the migration of lymphocytes across primary human HSECs, we found that lymphocyt ...[more]