Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects.
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ABSTRACT:
SUBMITTER: Lucanic M
PROVIDER: S-EPMC5321775 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects.
Lucanic Mark M Plummer W Todd WT Chen Esteban E Harke Jailynn J Foulger Anna C AC Onken Brian B Coleman-Hulbert Anna L AL Dumas Kathleen J KJ Guo Suzhen S Johnson Erik E Bhaumik Dipa D Xue Jian J Crist Anna B AB Presley Michael P MP Harinath Girish G Sedore Christine A CA Chamoli Manish M Kamat Shaunak S Chen Michelle K MK Angeli Suzanne S Chang Christina C Willis John H JH Edgar Daniel D Royal Mary Anne MA Chao Elizabeth A EA Patel Shobhna S Garrett Theo T Ibanez-Ventoso Carolina C Hope June J Kish Jason L JL Guo Max M Lithgow Gordon J GJ Driscoll Monica M Phillips Patrick C PC
Nature communications 20170221
Limiting the debilitating consequences of ageing is a major medical challenge of our time. Robust pharmacological interventions that promote healthy ageing across diverse genetic backgrounds may engage conserved longevity pathways. Here we report results from the Caenorhabditis Intervention Testing Program in assessing longevity variation across 22 Caenorhabditis strains spanning 3 species, using multiple replicates collected across three independent laboratories. Reproducibility between test si ...[more]
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