Dataset Information

Effect of environmentally-relevant concentrations of nonylphenol on sexual differentiation in zebrafish: a multi-generational study.

ABSTRACT: Nonylphenol (NP) is a persistent environmental chemical that can disrupt the organism's endocrine system, and is detected in the surface water and sea. In this study, we investigated whether NP can alter transcriptional expression of sexual differentiation-related genes. Three generations of zebrafish were exposed to 0, 2, 20 and 200??g·L-1 of NP, and transcriptional expression of sexual differentiation genes were assessed in 10, 20 and 40?dpf in the F1 and F2 generations. Growth of zebrafish exposed to 200??g·L-1 of NP was inhibited at 125?dpf in the F1 generation. 20??g·L-1 of NP resulted in 80% females in the F1 generation, but had no effect on the F2 generation. In terms of the sexual differentiation genes, the transcriptional expression of cyp19a1a and esr1 genes were upregulated in 20??g·L-1 of NP in the F1 generation. But expression of the sexual differentiation genes were not affected in the F2 generation. Overall, NP could affect sexual differentiation and gene transcriptional expression in the F1 generation. The tolerance of contaminant in the offsprings was improved at low concentration.

SUBMITTER: Sun D

PROVIDER: S-EPMC5322358 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Effect of environmentally-relevant concentrations of nonylphenol on sexual differentiation in zebrafish: a multi-generational study.

Sun Dong D Chen Qi Q He Ning N Diao Pan-Pan PP Jia Li-Xing LX Duan Shun-Shan SS

Scientific reports 20170223

Nonylphenol (NP) is a persistent environmental chemical that can disrupt the organism's endocrine system, and is detected in the surface water and sea. In this study, we investigated whether NP can alter transcriptional expression of sexual differentiation-related genes. Three generations of zebrafish were exposed to 0, 2, 20 and 200 μg·L<sup>-1</sup> of NP, and transcriptional expression of sexual differentiation genes were assessed in 10, 20 and 40 dpf in the F1 and F2 generations. Growth of z ...[more]

PMID: 28230098

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Dataset Information

Effect of environmentally-relevant concentrations of nonylphenol on sexual differentiation in zebrafish: a multi-generational study.

Publications

Effect of environmentally-relevant concentrations of nonylphenol on sexual differentiation in zebrafish: a multi-generational study.

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