A novel physiological role for cardiac myoglobin in lipid metabolism.

ABSTRACT: Continuous contractile activity of the heart is essential and the required energy is mostly provided by fatty acid (FA) oxidation. Myocardial lipid accumulation can lead to pathological responses, however the underlying mechanisms remain elusive. The role of myoglobin in dioxygen binding in cardiomyocytes and oxidative skeletal muscle has widely been appreciated. Our recent work established myoglobin as a protector of cardiac function in hypoxia and disease states. We here unravel a novel role of cardiac myoglobin in governing FA metabolism to ensure the physiological energy production through β-oxidation, preventing myocardial lipid accumulation and preserving cardiac functions. In vivo¹H magnetic resonance spectroscopy unveils a 3-fold higher deposition of lipids in mouse hear

SUBMITTER: Hendgen-Cotta UB 

PROVIDER: S-EPMC5322402 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature