Ontology highlight
ABSTRACT:
SUBMITTER: Cyrus C
PROVIDER: S-EPMC5322420 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Cyrus Cyril C Vatte Chittibabu C Borgio J Francis JF Al-Rubaish Abdullah A Chathoth Shahanas S Nasserullah Zaki A ZA Jarrash Sana Al SA Sulaiman Ahmed A Qutub Hatem H Alsaleem Hassan H Alzahrani Alhusain J AJ Steinberg Martin H MH Ali Amein K Al AK
BioMed research international 20170209
<i>Background and Objectives</i>. <i>β</i>-Thalassemia and sickle cell disease are genetic disorders characterized by reduced and abnormal <i>β</i>-globin chain production, respectively. The elevation of fetal hemoglobin (HbF) can ameliorate the severity of these disorders. In sickle cell disease patients, the HbF level elevation is associated with three quantitative trait loci (QTLs), <i>BCL11A</i>, <i>HBG</i>2 promoter, and <i>HBS1L-MYB</i> intergenic region. This study elucidates the existenc ...[more]