Ontology highlight
ABSTRACT:
SUBMITTER: Armitage AE
PROVIDER: S-EPMC5322583 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Armitage Andrew E AE Lim Pei Jin PJ Frost Joe N JN Pasricha Sant-Rayn SR Soilleux Elizabeth J EJ Evans Emma E Morovat Alireza A Santos Ana A Diaz Rebeca R Biggs Daniel D Davies Benjamin B Gileadi Uzi U Robbins Peter A PA Lakhal-Littleton Samira S Drakesmith Hal H
Journal of innate immunity 20160716 5
Withdrawal of iron from serum (hypoferraemia) is a conserved innate immune antimicrobial strategy that can withhold this critical nutrient from invading pathogens, impairing their growth. Hepcidin (Hamp1) is the master regulator of iron and its expression is induced by inflammation. Mice lacking Hamp1 from birth rapidly accumulate iron and are susceptible to infection by blood-dwelling siderophilic bacteria such as Vibrio vulnificus. In order to study the innate immune role of hepcidin against a ...[more]