Unknown

Dataset Information

0

HPV16 E6 seropositivity among cancer-free men with oral, anal or genital HPV16 infection.


ABSTRACT: Antibodies against the Human papillomavirus 16 (HPV16) E6 oncoprotein appear years prior to clinical diagnosis of anal and oropharyngeal cancer, but whether they develop around the time of HPV infection is unclear. Serum samples from 173 cancer-free men from the Human Papillomavirus Infection in Men (HIM) Study were tested for HPV antibodies and DNA. HPV16 E6 seropositivity was low among men with oral HPV16-infection (1/28; 3.6%, 95%CI=0.0%-18.4%), anal HPV16-infection (1/61; 1.6%, 95%CI=0.0%-8.8%), and 24-month persistent genital HPV16-infection (1/84; 1.2%, 0.0-6.5%). This suggests E6 seroconversion may not occur around the time of oral, anal, or genital HPV16 acquisition.

SUBMITTER: Beachler DC 

PROVIDER: S-EPMC5322843 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

HPV16 E6 seropositivity among cancer-free men with oral, anal or genital HPV16 infection.

Beachler Daniel C DC   Waterboer Tim T   Pierce Campbell Christine M ChM   Ingles Donna J DJ   Kuhs Krystle A Lang KA   Nyitray Alan G AG   Hildesheim Allan A   Pawlita Michael M   Kreimer Aimée R AR   Giuliano Anna R AR  

Papillomavirus research (Amsterdam, Netherlands) 20160728


Antibodies against the Human papillomavirus 16 (HPV16) E6 oncoprotein appear years prior to clinical diagnosis of anal and oropharyngeal cancer, but whether they develop around the time of HPV infection is unclear. Serum samples from 173 cancer-free men from the Human Papillomavirus Infection in Men (HIM) Study were tested for HPV antibodies and DNA. HPV16 E6 seropositivity was low among men with oral HPV16-infection (1/28; 3.6%, 95%CI=0.0%-18.4%), anal HPV16-infection (1/61; 1.6%, 95%CI=0.0%-8.  ...[more]

Similar Datasets

| S-EPMC4862406 | biostudies-literature
2025-05-07 | GSE293618 | GEO
| S-EPMC5482618 | biostudies-literature
| S-EPMC4295625 | biostudies-literature
| S-EPMC3534652 | biostudies-literature
| S-EPMC10970635 | biostudies-literature
| S-EPMC3685232 | biostudies-literature
| S-EPMC8770419 | biostudies-literature
| S-EPMC9430801 | biostudies-literature
| S-EPMC8436567 | biostudies-literature