Ontology highlight
ABSTRACT:
SUBMITTER: Mutazono M
PROVIDER: S-EPMC5322907 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Mutazono Masatoshi M Morita Misato M Tsukahara Chihiro C Chinen Madoka M Nishioka Shiori S Yumikake Tatsuhiro T Dohke Kohei K Sakamoto Misuzu M Ideue Takashi T Nakayama Jun-Ichi JI Ishii Kojiro K Tani Tokio T
PLoS genetics 20170223 2
In fission yeast, the formation of centromeric heterochromatin is induced through the RNA interference (RNAi)-mediated pathway. Some pre-mRNA splicing mutants (prp) exhibit defective formation of centromeric heterochromatin, suggesting that splicing factors play roles in the formation of heterochromatin, or alternatively that the defect is caused by impaired splicing of pre-mRNAs encoding RNAi factors. Herein, we demonstrate that the splicing factor spPrp16p is enriched at the centromere, and as ...[more]