Inhibition of never in mitosis A (NIMA)-related kinase-4 reduces survivin expression and sensitizes cancer cells to TRAIL-induced cell death.
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ABSTRACT:
SUBMITTER: Park SJ
PROVIDER: S-EPMC5323206 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Inhibition of never in mitosis A (NIMA)-related kinase-4 reduces survivin expression and sensitizes cancer cells to TRAIL-induced cell death.
Park So Jung SJ Jo Doo Sin DS Jo Se-Young SY Shin Dong Woon DW Shim Sangmi S Jo Yoon Kyung YK Shin Ji Hyun JH Ha Ye Jin YJ Jeong Seong-Yun SY Hwang Jung Jin JJ Kim Young Sam YS Suh Young-Ah YA Chang Jong Wook JW Kim Jin Cheon JC Cho Dong-Hyung DH
Oncotarget 20161001 40
The tumor necrosis factor-related apoptosis inducing ligand (TRAIL) preferentially induces apoptosis in cancer cells. However, many tumors are resistant to TRAIL-induced apoptosis, and resistance mechanisms are not fully understood. To identify novel regulatory molecules of TRAIL resistance, we screened a siRNA library targeting the human kinome, and NEK4 (NIMA-related kinase-4) was identified. Knockdown of NEK4 sensitized TRAIL-resistant cancer cells and in vivo xenografts to cell death. In con ...[more]
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