Ontology highlight
ABSTRACT:
SUBMITTER: Hertz DL
PROVIDER: S-EPMC5323433 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Hertz D L DL Kidwell K M KM Seewald N J NJ Gersch C L CL Desta Z Z Flockhart D A DA Storniolo A-M AM Stearns V V Skaar T C TC Hayes D F DF Henry N L NL Rae J M JM
The pharmacogenomics journal 20160823 6
Discovery of clinical and genetic predictors of exemestane pharmacokinetics was attempted in 246 postmenopausal patients with breast cancer enrolled on a prospective clinical study. A sample was collected 2 h after exemestane dosing at a 1- or 3-month study visit to measure drug concentration. The primary hypothesis was that patients carrying the low-activity CYP3A4*22 (rs35599367) single-nucleotide polymorphism (SNP) would have greater exemestane concentration. Additional SNPs in genes relevant ...[more]