ZnO nanoparticles act as supportive therapy in DSS-induced ulcerative colitis in mice by maintaining gut homeostasis and activating Nrf2 signaling.
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ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC5324050 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
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ZnO nanoparticles act as supportive therapy in DSS-induced ulcerative colitis in mice by maintaining gut homeostasis and activating Nrf2 signaling.
Li Jinquan J Li Jinquan J Chen Hanqing H Wang Bing B Cai Chengxu C Yang Xu X Chai Zhifang Z Feng Weiyue W
Scientific reports 20170224
Inflammatory bowel diseases (IBD) are widespread inflammatory diseases that cause debilitating health problems including cancer. In this study, we show that ZnO nanoparticle (ZnONP) treatment has markedly dose-dependent effects on the remission of dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. We demonstrate the mechanism involves the antioxidant and anti-inflammatory abilities of ZnONPs to suppress ROS and malondialdehyde (MDA) production; increase GSH level; suppress proinfla ...[more]
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