Ontology highlight
ABSTRACT:
SUBMITTER: Ban Z
PROVIDER: S-EPMC5324142 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Ban Zsofia Z Maurischat Paul P Benz Verena V Brix Sarah S Sonnenburg Anna A Schuler Gerhard G Klopfleisch Robert R Rothe Michael M Gustafsson Jan-Åke JÅ Foryst-Ludwig Anna A Kintscher Ulrich U
Scientific reports 20170224
Estrogen receptor alpha (ERα) is a major regulator of metabolic processes in obesity. In this study we aimed to define the relevance of adipose tissue ERα during high-fat diet (HFD)-induced obesity using female aP2-Cre<sup>-/+</sup>/ERα<sup>fl/fl</sup> mice (atERαKO). HFD did not affect body weight or glucose metabolism in atERαKO- compared to control mice. Surprisingly, HFD feeding markedly increased mortality in atERαKO mice associated with a destructive bacterial infection of the uterus drive ...[more]