Cluster analysis of sputum cytokine-high profiles reveals diversity in T(h)2-high asthma patients.

ABSTRACT:

Background

Asthma is characterized by a heterogeneous inflammatory profile and can be subdivided into T(h)2-high and T(h)2-low airway inflammation. Profiling of a broader panel of airway cytokines in large unselected patient cohorts is lacking.

Methods

Patients (n = 205) were defined as being "cytokine-low/high" if sputum mRNA expression of a particular cytokine was outside the respective 10^th/90^th percentile range of the control group (n = 80). Unsupervised hierarchical clustering was used to determine clusters based on sputum cytokine profiles.

Results

Half of patients (n = 108; 52.6%) had a classical T(h)2-high ("IL-4-, IL-5- and/or IL-13-high") sputum cytokine profile. Unsupervised cluster analysis revealed 5 clusters. Patients with an "IL-4-

SUBMITTER: Seys SF 

PROVIDER: S-EPMC5324270 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature