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Monocyte-derived dendritic cells enhance protection against secondary influenza challenge by controlling the switch in CD8⁺ T-cell immunodominance.

ABSTRACT: Influenza virus infection triggers an increase in the number of monocyte-derived dendritic cells (moDCs) in the respiratory tract, but the role of these cells during antiviral immunity is still unclear. Here we show that during influenza infection, moDCs dominate the late activation of CD8⁺ T cells and trigger the switch in immunodominance of the CD8⁺ T-cell response from acidic polymerase specificity to nucleoprotein specificity. Abrogation of monocyte recruitment or depletion of moDCs strongly compromised host resistance to secondary influenza challenge. These findings underscore a novel function of moDCs in the antiviral response to influenza virus, and have important implications for vaccine design.

SUBMITTER: Cruz JL

PROVIDER: S-EPMC5324604 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Monocyte-derived dendritic cells enhance protection against secondary influenza challenge by controlling the switch in CD8+ T-cell immunodominance.

Cruz Jazmina L G JL Pérez-Girón José V JV Lüdtke Anja A Gómez-Medina Sergio S Ruibal Paula P Idoyaga Juliana J Muñoz-Fontela César C

European journal of immunology 20161209 2

Influenza virus infection triggers an increase in the number of monocyte-derived dendritic cells (moDCs) in the respiratory tract, but the role of these cells during antiviral immunity is still unclear. Here we show that during influenza infection, moDCs dominate the late activation of CD8+ T cells and trigger the switch in immunodominance of the CD8+ T-cell response from acidic polymerase specificity to nucleoprotein specificity. Abrogation of monocyte recruitment or deple ...[more]

PMID: 27859043

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