Copper is a Cofactor of the Formylglycine-Generating Enzyme.
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ABSTRACT:
SUBMITTER: Knop M
PROVIDER: S-EPMC5324649 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
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Copper is a Cofactor of the Formylglycine-Generating Enzyme.
Knop Matthias M Dang Thanh Quy TQ Jeschke Gunnar G Seebeck Florian P FP
Chembiochem : a European journal of chemical biology 20161213 2
Formylglycine-generating enzyme (FGE) is an O<sub>2</sub> -utilizing oxidase that converts specific cysteine residues of client proteins to formylglycine. We show that Cu<sup>I</sup> is an integral cofactor of this enzyme and binds with high affinity (K<sub>D</sub> =of 10<sup>-17</sup> m) to a pair of active-site cysteines. These findings establish FGE as a novel type of copper enzyme. ...[more]
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