Ontology highlight
ABSTRACT:
SUBMITTER: Sun S
PROVIDER: S-EPMC5324710 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Sun Shuohao S Xu Qian Q Guo Changxiong C Guan Yun Y Liu Qin Q Dong Xinzhong X
Neuron 20170201 4
Coding of itch versus pain has been heatedly debated for decades. However, the current coding theories (labeled line, intensity, and selectivity theory) cannot accommodate all experimental observations. Here we identified a subset of spinal interneurons, labeled by gastrin-releasing peptide (Grp), that receive direct synaptic input from both pain and itch primary sensory neurons. When activated, these Grp<sup>+</sup> neurons generated rarely seen, simultaneous robust pain and itch responses that ...[more]