Ontology highlight
ABSTRACT:
SUBMITTER: Baek A
PROVIDER: S-EPMC5324842 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Baek Ahruem A Yoon Soojin S Kim Jean J Baek Yu Mi YM Park Hanna H Lim Daehan D Chung Hyewon H Kim Dong-Eun DE
Autophagy 20170103 2
Contribution of autophagy and regulation of related proteins to the degeneration of retinal pigment epithelium (RPE) in age-related macular degeneration (AMD) remain unknown. We report that upregulation of KRT8 (keratin 8) as well as its phosphorylation are accompanied with autophagy and attenuated with the inhibition of autophagy in RPE cells under oxidative stress. KRT8 appears to have a dual role in RPE pathophysiology. While increased expression of KRT8 following autophagy provides a cytopro ...[more]