Ontology highlight
ABSTRACT:
SUBMITTER: Llorca-Cardenosa MJ
PROVIDER: S-EPMC5325374 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Llorca-Cardeñosa Marta Jessica MJ Fleitas Tania T Ibarrola-Villava Maider M Peña-Chilet María M Mongort Cristina C Martinez-Ciarpaglini Carolina C Navarro Lara L Gambardella Valentina V Castillo Josefa J Roselló Susana S Navarro Samuel S Ribas Gloria G Cervantes Andrés A
Oncotarget 20160901 39
Gastric cancer (GC) pathogenesis involves genetic, epigenetic and environmental factors. Epigenetic alterations, such as DNA methylation are considered pivotal in the inactivation of tumor-related genes. We assessed a methylation panel of 5 genes to study their association to GC progression and microsatellite instability (MSI), and studied the role of RUNX3 in GC pathogenesis and the tumor immune microenvironment.The methylation status of 47 promoter-CpG islands was studied through MALDI-TOF mas ...[more]