Ontology highlight
ABSTRACT:
SUBMITTER: Lindqvist CM
PROVIDER: S-EPMC5325426 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Lindqvist C Mårten CM Lundmark Anders A Nordlund Jessica J Freyhult Eva E Ekman Diana D Carlsson Almlöf Jonas J Raine Amanda A Övernäs Elin E Abrahamsson Jonas J Frost Britt-Marie BM Grandér Dan D Heyman Mats M Palle Josefine J Forestier Erik E Lönnerholm Gudmar G Berglund Eva C EC Syvänen Ann-Christine AC
Oncotarget 20160901 39
To characterize the mutational patterns of acute lymphoblastic leukemia (ALL) we performed deep next generation sequencing of 872 cancer genes in 172 diagnostic and 24 relapse samples from 172 pediatric ALL patients. We found an overall greater mutational burden and more driver mutations in T-cell ALL (T-ALL) patients compared to B-cell precursor ALL (BCP-ALL) patients. In addition, the majority of the mutations in T-ALL had occurred in the original leukemic clone, while most of the mutations in ...[more]