Ontology highlight
ABSTRACT:
SUBMITTER: Novais FO
PROVIDER: S-EPMC5325592 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Novais Fernanda O FO Carvalho Augusto M AM Clark Megan L ML Carvalho Lucas P LP Beiting Daniel P DP Brodsky Igor E IE Carvalho Edgar M EM Scott Phillip P
PLoS pathogens 20170213 2
Deregulated CD8+ T cell cytotoxicity plays a central role in enhancing disease severity in several conditions. However, we have little understanding of the mechanisms by which immunopathology develops as a consequence of cytotoxicity. Using murine models of inflammation induced by the protozoan parasite leishmania, and data obtained from patients with cutaneous leishmaniasis, we uncovered a previously unrecognized role for NLRP3 inflammasome activation and IL-1β release as a detrimental conseque ...[more]