Ontology highlight
ABSTRACT:
SUBMITTER: Ganesan R
PROVIDER: S-EPMC5325604 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Ganesan Raja R Hos Nina Judith NJ Gutierrez Saray S Fischer Julia J Stepek Joanna Magdalena JM Daglidu Evmorphia E Krönke Martin M Robinson Nirmal N
PLoS pathogens 20170213 2
During intracellular infections, autophagy significantly contributes to the elimination of pathogens, regulation of pro-inflammatory signaling, secretion of immune mediators and in coordinating the adaptive immune system. Intracellular pathogens such as S. Typhimurium have evolved mechanisms to circumvent autophagy. However, the regulatory mechanisms targeted by S. Typhimurium to modulate autophagy have not been fully resolved. Here we report that cytosolic energy loss during S. Typhimurium infe ...[more]