Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline.
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ABSTRACT:
SUBMITTER: Leal SL
PROVIDER: S-EPMC5325620 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline.
Leal Stephanie L SL Landau Susan M SM Bell Rachel K RK Jagust William J WJ
eLife 20170208
The amyloid hypothesis suggests that beta-amyloid (Aβ) deposition leads to alterations in neural function and ultimately to cognitive decline in Alzheimer's disease. However, factors that underlie Aβ deposition are incompletely understood. One proposed model suggests that synaptic activity leads to increased Aβ deposition. More specifically, hyperactivity in the hippocampus may be detrimental and could be one factor that drives Aβ deposition. To test this model, we examined the relationship betw ...[more]
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