Ontology highlight
ABSTRACT:
SUBMITTER: Cheng L
PROVIDER: S-EPMC5326762 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Cheng Lin L Yu Honghua H Yan Naihong N Lai Kunbei K Xiang Mengqing M
Frontiers in cellular neuroscience 20170227
Hypoxia-inducible factor (HIF) is a transcription factor that facilitates cellular adaptation to hypoxia and ischemia. Long-standing evidence suggests that one isotype of HIF, HIF-1α, is involved in the pathogenesis of various solid tumors and cardiac diseases. However, the role of HIF-1α in retina remains poorly understood. HIF-1α has been recognized as neuroprotective in cerebral ischemia in the past two decades. Additionally, an increasing number of studies has shown that HIF-1α and its targe ...[more]