Ontology highlight
ABSTRACT:
SUBMITTER: Choudhary P
PROVIDER: S-EPMC5326799 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Choudhary Parul P Armstrong Emma J EJ Jorgensen Csilla C CC Piotrowski Mary M Barthmes Maria M Torella Rubben R Johnston Sarah E SE Maruyama Yuya Y Janiszewski John S JS Storer R Ian RI Skerratt Sarah E SE Benn Caroline L CL
Frontiers in molecular neuroscience 20170227
Cholinergic hypofunction is associated with decreased attention and cognitive deficits in the central nervous system in addition to compromised motor function. Consequently, stimulation of cholinergic neurotransmission is a rational therapeutic approach for the potential treatment of a variety of neurological conditions. High affinity choline uptake (HACU) into acetylcholine (ACh)-synthesizing neurons is critically mediated by the sodium- and pH-dependent high-affinity choline transporter (CHT, ...[more]