Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action.
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ABSTRACT:
SUBMITTER: Ai XY
PROVIDER: S-EPMC5327358 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action.
Ai Xiao-Yu XY Liu Hui-Juan HJ Lu Cheng C Liang Cai-Li CL Sun Yan Y Chen Shuang S Sun Bo B Li Yang Y Liu Yan-Rong YR Zhang Qiang Q Liu Xue-Qiang XQ Xiao Ting T Jing Xue-Shuang XS Sun Tao T Zhou Hong-Gang HG Yang Cheng C
Theranostics 20170105 2
Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies showed that PnAg could accelerate dermal wound healing and strong inflammation control in Sprague-Dawley rats (SD rat) and Bama minipigs. Due to its low solubility, PnAg led to low toxicity and blood enric ...[more]
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