Ontology highlight
ABSTRACT:
SUBMITTER: Friocourt F
PROVIDER: S-EPMC5327424 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Friocourt François F Lafont Anne-Gaelle AG Kress Clémence C Pain Bertrand B Manceau Marie M Dufour Sylvie S Chédotal Alain A
Scientific reports 20170227
During development, midline crossing by axons brings into play highly conserved families of receptors and ligands. The interaction between the secreted ligand Netrin-1 and its receptor Deleted in Colorectal Carcinoma (DCC) is thought to control midline attraction of crossing axons. Here, we studied the evolution of this ligand/receptor couple in birds taking advantage of a wealth of newly sequenced genomes. From phylogeny and synteny analyses we can infer that the DCC gene has been conserved in ...[more]